Publications by authors named "D H Crowell"
Fetuin-A is a serum glycoprotein synthesized and secreted into blood by the liver and whose main physiological function is the inhibition of ectopic calcification. However, a number of studies have demonstrated that it is a multifunctional protein. For example, endocytic uptake of fetuin-A by tumor cells resulting in rapid cellular adhesion and spreading has been reported.
View Article and Find Full Text PDFArticle Synopsis
- Recent studies show that while certain chemicals increase hemangiosarcoma (HSA) incidence in mice, the implications for humans remain unclear.
- Canine HSAs provide a valuable model for understanding human HSAs, exhibiting distinct cellular phenotypes such as expressing endothelial cell (EC) markers more reliably than hematopoietic stem cell (HSC) markers.
- Key differences were noted: human HSAs showed consistent HSC marker expression indicating less differentiation compared to canine and mouse HSAs, while both human and canine HSAs displayed late-stage EC maturation markers absent in mice, highlighting species variability in HSA development and translating risk from animal studies to humans.
C-X-C chemokine receptor type 7 (CXCR7) is involved in cardiac and immune pathophysiology. We report the discovery of a novel 1,4-diazepine CXCR7 modulator, demonstrating for the first time the role of pharmacological CXCR7 intervention in cardiac repair. Structure-activity-relationship (SAR) studies demonstrated that a net reduction in lipophilicity (log D) and an incorporation of saturated ring systems yielded compounds with good CXCR7 potencies and improvements in oxidative metabolic stability in human-liver microsomes (HLM).
View Article and Find Full Text PDFObjective: To acoustically evaluate the cries of SIDS infants and compare these cry features to a group of healthy term (HT) infants, as well as previously published results for SIDS infants.
Methods: Pain-induced crying episodes were collected from four infants during the first weeks of life that later died of SIDS. Temporal and spectral features of each crying episode were characterized based on measures of cry duration, cry fundamental frequency (F0), and cry formant frequencies (F1 and F2).
Isopentenyl diphosphate isomerase (IPPI) of the spruce budworm, Choristoneura fumiferana, and of the tobacco hornworm, Manduca sexta, was cloned and its catalytic properties assessed. In the presence of Mg(2+) or Mn(2+), the recombinant protein from C. fumiferana (CfIPPI) efficiently isomerized IPP to dimethylallyl diphosphate (DMAPP).
View Article and Find Full Text PDF