Effects of prescreening for likelihood ratio approaches in the forensic identification of source problems.

Source prescreening is a methodology where forensic examiners select samples that are similar to given trace evidence to represent the background population. This background evidence helps assign a value of evidence using a likelihood ratio or Bayes factor. A potential benefit of prescreening is a mitigation of effects from subpopulation structures within the alternative source population by isolating the relevant subpopulation.

Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus .

The noncoding genome presents a largely untapped source of new biological insights, including thousands of long noncoding RNA (lncRNA) loci. While lncRNA dysregulation has been reported in myeloid malignancies, their functional relevance remains to be systematically interrogated. We performed CRISPRi screens of lncRNA signatures from normal and malignant hematopoietic cells and identified as a myeloid leukemia dependency.

Real-Time Characterization of Clonal Fate Decisions in Complex Leukemia Samples by Fluorescent Genetic Barcoding.

Clonal heterogeneity in acute myeloid leukemia (AML) forms the basis for treatment failure and relapse. Attempts to decipher clonal evolution and clonal competition primarily depend on deep sequencing approaches. However, this prevents the experimental confirmation of the identified disease-relevant traits on the same cell material.

Reporting of pneumothorax in association with vaping devices and electronic cigarettes.

Vaping may lead to spontaneous pneumothorax, but there are few published reports on this phenomenon. We present a case of vaping-related pneumothorax and make recommendations for structured reporting of this emerging cause for pneumothorax. A normal-weight 34-year-old male presented to our emergency department with dyspnoea and back pain increasing over 24 hours.

Extensive Ossification of the Achilles Tendon with and without Acute Fracture: A Scoping Review.

Extensive Ossification of the Achilles Tendon (EOAT) is an uncommon condition characterized by the presence of heterotopic ossification within the substance of the Achilles Tendon and is distinct from other tendinopathies associated with tendon mineralization. The purpose of this scoping review of the literature on EOAT is to describe the pathogenesis, patient population, presentation, management, and outcomes of this rare condition. Fifty-four articles were included in the scoping review after screening and selection.