Publications by authors named "D H Avery"
Article Synopsis
- T follicular helper (Tfh) cells, which are important for antibody production, rely heavily on the immunoreceptor PD-1, and its deficiency leads to weakened Tfh functions and impaired immune responses in mice.
- Individuals lacking PD-1 or PD-L1 demonstrate fewer memory B cells and diminished antibody responses, highlighting the critical role of these molecules in immune system functionality.
- PD-1 influences both the intrinsic and extrinsic aspects of B cell memory and antibody production, suggesting that disruptions in PD-1 signaling can lead to complications in immune responses, especially during anti-PD-1-PD-L1 therapies.
Obesity is a metabolic disease resulting from excess body fat accumulation associated with chronic systemic inflammation. Obesity has been shown to impact the function and activity of neutrophils, macrophages, and T cells, contributing to higher circulating levels of pro-inflammatory cytokines. Biomaterial surface properties such as roughness and hydrophilicity can influence the behavior of immune cells in the peri-implant microenvironment.
View Article and Find Full Text PDFPlasma proteomics could enhance risk prediction for multiple diseases beyond conventional risk factors or polygenic scores (PS). To assess utility of proteomics for risk prediction of ischemic heart disease (IHD) compared with conventional risk factors and PS in Chinese and European populations. A nested case-cohort study measured plasma levels of 2923 proteins using Olink Explore panel in ~ 4000 Chinese adults (1976 incident IHD cases and 2001 sub-cohort controls).
View Article and Find Full Text PDFArticle Synopsis
- Recent guidelines suggest that individuals with prehypertension (130/80 to 139/89 mm Hg) should consider antihypertensive treatment; this study assesses the cost-effectiveness of three interventions: salt substitution, antihypertensive drugs, and their combination in Chinese adults.
- A Markov cohort model was used to estimate the impact of these interventions on cardiovascular disease events, costs, and quality-adjusted life years (QALYs), utilizing data from the China Kadoorie Biobank.
- The findings indicate that salt substitution is the most cost-effective strategy for prehypertensive individuals starting at age 40, while a combination intervention is best for those at high cardiovascular risk; beginning these interventions at younger ages can lead to more