A simulation-based approach for investigating the dynamics of rebound effects in the circular economy: A case of use-oriented product/service system.

Current research in Circular Economy (CE) fails to address the occurrence of Rebound Effects (RE), which are systemic and behavioural responses to the implementation of interventions hindering the potential sustainability benefits. This paper aims to advance the academic discussion and the practical consideration of RE by exploring the potential of using System Dynamics (SD) to enable the ex-ante identification of potential RE of CE initiatives. A five-stage simulation-based approach for the identification and mitigation of potential rebound effects (AIMRE) is proposed.

Barriers to employing digital technologies for a circular economy: A multi-level perspective.

Industry 4.0 and digital technologies might significantly impact resource optimization in a smart circular economy. However, adopting digital technologies is not easy due to barriers that may arise during this process.

Analysis of national policies for Circular Economy transitions: Modelling and simulating the Brazilian industrial agreement for electrical and electronic equipment.

Public policies, incentives, and infrastructure are top-down instruments that can align stakeholders' roles and expectations for Circular Economy (CE) transitions, but it is crucial to analyse the possible effects of such instruments before implementation. This research investigates the Brazilian Industrial Agreement for Electrical and Electronic Equipment (BIAEEE) that governs the responsibilities and targets for nationwide collection and treatment of Waste from Electrical and Electronic Equipment (WEEE). A system dynamics simulation model is adapted for the use of smartphones in Brazil, and interventions focused on the collection of end-of-life products are examined against the BIAEEE targets.

Therapeutic potential of adipose stem cell-derived conditioned medium against pulmonary hypertension and lung fibrosis.

Background And Purpose: Pulmonary hypertension (PH) and pulmonary fibrosis (PF) are life threatening cardiopulmonary diseases. Existing pharmacological interventions have failed to improve clinical outcomes or reduce disease-associated mortality. Emerging evidence suggests that stem cells offer an effective treatment approach against various pathological conditions.

Stem cell therapy restores viscoelastic properties of myocardium in rat model of hypertension.

Extensive remodeling of the myocardium is seen in a variety of cardiovascular diseases, including systemic hypertension. Stem cell therapy has been proposed to improve the clinical outcomes of hypertension, and we hypothesized that changes in mechanical properties of the myocardium would accompany the progression of disease and the results of treatment conditions. Using spontaneously hypertensive rats (SHR) as a model of hypertension, we treated 13-week-old hypertensive rats with a single injection of adipose-derived stem cells (ADSC) isolated from a normotensive control.