Publications by authors named "D Guthrie"
Monoamine transporters function in neuronal membranes to control extracellular concentrations of their substrates. Cell-surface expression of transporters is regulated by substrates and intracellular signaling, but the underlying mechanisms remain unclear. Here, we found that substrates of the dopamine transporter (DAT), amphetamine and dopamine, synergize with protein kinase C (PKC)-dependent DAT ubiquitination to markedly elevate clathrin-mediated endocytosis of DAT, which is accompanied by DAT movement out of plasma membrane protrusions with a negative curvature.
View Article and Find Full Text PDFArticle Synopsis
- - The study analyzed risk factors for cognitive decline using data from a Canadian home care instrument, focusing on clients aged 65+ with two assessments from 2001 to 2020.
- - Of the 146,187 participants, 25.2% showed a decline in their Cognitive Performance Scale (CPS) score, with significant predictors including age, dementia diagnosis, physical inactivity, and caregiver burden.
- - The findings emphasize the need for early identification of modifiable risk factors to enhance care plans and improve the overall well-being of clients and their families.
Article Synopsis
- - Two methods are described for synthesizing ()-(+)-1,2-epoxy-5-hexene using cheap and accessible materials.
- - The first method involves a two-step process with mCPBA epoxidation and chiral resolution, yielding 24-30%.
- - The second method starts with ()-epichlorohydrin, achieving 55-60% yield and high purity through ring-opening and closure reactions. Both methods have been tested successfully on scales of 100-200 grams.
Malignant catatonia is a rare, life-threatening variant of catatonia requiring prompt treatment. Malignant catatonia is characterized by typical catatonia symptoms of psychomotor, neurologic, and behavioral changes complicated by autonomic instability, with an estimated mortality rate of 50% or more when untreated. Electroconvulsive therapy (ECT) is considered the definitive and most effective treatment for malignant catatonia, with minimal literature on the efficacy of pharmacological interventions alone.
View Article and Find Full Text PDF