Publications by authors named "D Gunasekera"
Objective: Our aim is to determine the comparative effectiveness of unimodality organ preservation surgery versus radiotherapy on oncological and functional outcomes in patients with early hypopharyngeal cancer.
Introduction: Early hypopharyngeal cancer is difficult to detect and therefore rarely diagnosed, as patients are often asymptomatic. Radiotherapy is considered the main treatment, although this modality has been compared to the previously used open surgical approach, which may not reflect current surgical options.
Background: Residual, recurrent, and second primary head and neck cancers are on the rise. This is largely driven by a younger age at diagnosis and increasingly targeted chemoradiotherapy options. Salvage surgery remains the only curative intent option in this cohort of patients.
View Article and Find Full Text PDFBackground: There is a shortage of rapid, accurate, and low-cost assays for diagnosing enteric fever. The dual-path platform for typhoid (DPPT) assay had high accuracy in retrospective studies with banked plasma samples. We aimed to evaluate the diagnostic accuracy of the DPPT assay in a prospective study using fingerstick capillary blood.
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- There is a significant need for a reliable point-of-care diagnostic test for typhoid, and recent research focused on two specific antigens (LPS and HlyE) that help differentiate typhoid from other infections.
- A study evaluated the Dual Path Platform (DPP) Typhoid assay's effectiveness using archived serum samples, showing a sensitivity of 97.8% and specificity of 65.3% at manufacturer's thresholds, with improved overall accuracy at optimal thresholds.
- The DPP Typhoid assay outperformed other rapid diagnostic tests in the same study cohort, highlighting its potential for high diagnostic accuracy, although further adjustments to the testing thresholds are suggested to enhance its performance.
Background: Almost half of severe hemophilia A (HA) cases are caused by an intron 22 inversion (Int22Inv) mutation, which truncates the 26-exon F8 messenger RNA (mRNA) after exon 22. Another F8 transcript, F8, is initiated from within F8-intron-22. F8 mRNA consists of a short exon spliced to exons 23 to 26 and is expressed in multiple human cell types.
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