Publications by authors named "D Guha"
ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics.
Genomics Proteomics Bioinformatics
November 2024
Article Synopsis
- Mass spectrometry (MS) is a key technique used for identifying and understanding proteins, which is important for fields like personalized medicine and systems biology.
- The development of ProtPipe aims to simplify MS data analysis by automating processes like data quality control, sample filtering, and normalization, making it easier to handle complex datasets.
- ProtPipe also offers various downstream analyses, such as identifying differences in protein abundance and visualizing interactions, and is available as an open-source tool with a user-friendly interface at https://github.com/NIH-CARD/ProtPipe.
Background: Degenerative cervical myelopathy (DCM) occurs when spondylotic changes compress the spinal cord and cause neurologic dysfunction. Because of a lack of comparative data on nonoperative care versus surgery for DCM, it has been difficult to support patients through the shared decision-making process regarding treatment options. Our objective was to synthesize the best available data in a manner that helps clinicians and patients to weigh the differences between nonoperative care and surgery at different ages and disease severity.
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- Degenerative Cervical Myelopathy impacts patients significantly, and understanding their preferences for surgery is crucial for shared decision-making.
- A study surveyed patients with cervical stenosis on factors like neurologic function and surgery risks, revealing that lower extremity function is their top priority, while dysphagia and upper extremity function are also important.
- Results indicate that patients who have undergone surgery view neurologic function as less critical compared to complications, emphasizing the need for effective communication in treatment choices.
Background: A composite endpoint (CEP) is a measure comprising 2 or more separate component outcomes. The use of these constructs is increasing. We sought to conduct a systematic review on the usage, quality of reporting, and appropriate use of CEPs in spine surgery research.
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