Publications by authors named "D Gueth"
The endothelial lining and its outer lipid membrane are the first major barriers drug molecules encounter upon intravenous administration. Our previous work identified lipid analogs that counteract plasma membrane barrier function for a series of amphiphilic drugs. For example, short-chain sphingolipids (SCS), like N-octanoyl-glucosylceramide, effectively elevated doxorubicin accumulation in tumor cells, both in vitro and in vivo, and in endothelial cells, whereas other (normal) cells remained unaffected.
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- The effectiveness of bioactive drugs in cancer treatment is limited by their ability to cross cell membranes, which often leads to therapy resistance due to insufficient drug accumulation inside cells.
- Researchers discovered a mechanism that enhances the movement of the well-known anti-cancer drug doxorubicin across cell membranes, using lipid analogues to create a temporary channel that aids drug translocation.
- Their findings, supported by molecular simulations and tests on genetically modified mice with breast cancer, highlight how membrane structure restricts drug efficacy and offer a potential solution for improving the effectiveness of existing cancer treatments.