Publications by authors named "D Guery"
Article Synopsis
- The study aimed to evaluate how consistently different examiners score medical students during a neurology OSCE, focusing on the influence of examiner characteristics like specialty and gender.
- During the mock OSCE, video recordings of student performances were scored by physicians, and the reliability of scores was measured using a statistical method called intraclass correlation coefficient.
- Results showed good agreement for checklist scores but only moderate agreement for global ratings, with no impact from specialty on scoring but a correlation indicating that male examiners tended to give lower global ratings.
Early-Stage Contactin-Associated Protein-like 2 Limbic Encephalitis: Clues for Diagnosis.
Neurol Neuroimmunol Neuroinflamm
January 2023
Background And Objectives: Previous studies suggested that autoimmune limbic encephalitis with antibodies against contactin-associated protein-like 2 (CASPR2-encephalitis) is clinically heterogeneous and progresses slowly, preventing its early recognition. We aimed to describe the onset and progression of CASPR2-encephalitis and to assess long-term outcomes.
Methods: We retrospectively analyzed the medical records of all patients whose CSF tested positive for anti-CASPR2 antibodies in our center between 2006 and 2020.
Article Synopsis
- The study aimed to analyze how epilepsy develops in patients with LGI1 antibody-associated limbic encephalitis and to identify factors linked to drug-resistant epilepsy (DRE).
- Researchers conducted a retrospective review of 39 patients' medical data from two epilepsy centers over a 14-year period, focusing on seizure history and responses to anti-seizure medications.
- Results showed that 28% of patients achieved epilepsy remission, with longer delays in starting treatment linked to persistent epilepsy, while MRI changes, especially hippocampal atrophy, were main predictors of developing DRE.
Clinical Management of Drug Resistant Epilepsy: A Review on Current Strategies.
Neuropsychiatr Dis Treat
July 2021
Drug resistant epilepsy (DRE) is defined as the persistence of seizures despite at least two syndrome-adapted antiseizure drugs (ASD) used at efficacious daily dose. Despite the increasing number of available ASD, about a third of patients with epilepsy still suffer from drug resistance. Several factors are associated with the risk of evolution to DRE in patients with newly diagnosed epilepsy, including epilepsy onset in the infancy, intellectual disability, symptomatic epilepsy and abnormal neurological exam.
View Article and Find Full Text PDFClinical failure of natalizumab in multiple sclerosis: Specific causes and strategy.
Rev Neurol (Paris)
December 2021
Background: Natalizumab is a very effective treatment of multiple sclerosis (MS). Failure is rare and should lead to consider some specific etiologies. The purpose of our study was to describe causes of subacute neurological events under natalizumab.
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