Publications by authors named "D Guerrero-Setas"
Pancreatic ductal adenocarcinoma represents one of the solid tumors showing the worst prognosis worldwide, with a high recurrence rate after adjuvant or neoadjuvant therapy. Circulating tumor DNA analysis raised as a promising non-invasive tool to characterize tumor genomics and to assess treatment response. In this study, surgical tumor tissue and sequential blood samples were analyzed by next-generation sequencing and were correlated with clinical and pathological characteristics.
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- The study focuses on a 65-year-old male patient with a rare case of primary cutaneous acral CD8-positive lymphoproliferative disorder, presenting as a lesion in the right thigh rather than the usual acral locations.
- The lesion, measuring 2.5 cm, showed medium-sized atypical lymphocytes expressing CD3, CD8, and TIA-1, along with CD68 positivity, indicating a specific type of lymphocytic infiltration.
- During follow-up, the patient developed a recurrence in the abdomen, highlighting the importance of recognizing this condition to distinguish it from more aggressive T-cell lymphomas that may have similar marker expressions.
Article Synopsis
- Biphasic papillary renal cell carcinoma (PRCC) is a rare subtype of PRCC with less than 70 reported cases, characterized by a biphasic morphology that includes squamoid features.
- This study analyzed 17 cases of biphasic PRCC, finding that the average age was 62 years, with a slight male predominance, and most tumors were confined to the kidney, though a few exhibited metastasis.
- Immunohistochemical analysis revealed that biphasic PRCC tumors show strong expression of specific markers like PAX8 and keratin 7, and about a third of cases had mutations in the MET gene, indicating a potential for further research into their molecular characteristics and behavior.
Background: Colon cancer (CC) is a heterogeneous disease that is categorized into four Consensus Molecular Subtypes (CMS) according to gene expression. Patients with loco-regional CC (stages II/III) lack prognostic factors, making it essential to analyze new molecular markers that can delineate more aggressive tumors. Aberrant methylation of genes that are essential in crucial mechanisms such as epithelial mesenchymal transition (EMT) contributes to tumor progression in CC.
View Article and Find Full Text PDFMolecular characterization of colorectal cancer has helped us understand better the biology of the disease. However, previous efforts have yet to provide significant clinical value in order to be integrated into clinical practice for patients with early-stage colon cancer (CC). The purpose of this study was to assess PD-L1, GLUT-1, e-cadherin, MUC2, CDX2, and microsatellite instability (dMMR) and to propose a risk-panel with prognostic capabilities.
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