Publications by authors named "D Guasti"
Drugs able to efficiently counteract the progression of multiple sclerosis (MS) are still an unmet need. Numerous preclinical evidence indicates that reactive oxygen-generating enzyme myeloperoxidase (MPO), expressed by neutrophils and microglia, might play a key role in neurodegenerative disorders. Then, the MPO inhibition has been evaluated in clinical trials in Parkinson's and multiple system atrophy patients, and a clinical trial for the treatment of amyotrophic lateral sclerosis is underway.
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- Organogenesis in the uterus occurs under low oxygen levels, but preterm birth exposes infants to high oxygen, which can harm organ development and lead to conditions like necrotizing enterocolitis.
- The study investigates the role of the β3-adrenoreceptor (β3-AR) in protecting the ileum from damage caused by high oxygen levels in newborn rat pups, using a selective β3-AR agonist, BRL37344.
- Results show that a 3 mg/kg dose of BRL37344 mitigates some harmful changes caused by hyperoxia, highlighting its potential as a therapeutic approach for addressing complications related to premature birth and excessive oxygen exposure.
Hyponatremia is the prevalent electrolyte imbalance in cancer patients, and it is associated with a worse outcome. Notably, emerging clinical evidence suggests that hyponatremia adversely influences the response to anticancer treatments. Therefore, this study aims to investigate how reduced extracellular [Na] affects the responsiveness of different cancer cell lines (from human colon adenocarcinoma, neuroblastoma, and small cell lung cancer) to cisplatin and the underlying potential mechanisms.
View Article and Find Full Text PDFThe crosstalk between the chromaffin and adrenocortical cells is essential for the endocrine activity of the adrenal glands. This interaction is also likely important for tumorigenesis and progression of adrenocortical cancer and pheochromocytoma. We developed a unique in vitro 3D model of the whole adrenal gland called Adrenoid consisting in adrenocortical carcinoma H295R and pheochromocytoma MTT cell lines.
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- The study investigates the relationship between autoimmunity and mitochondrial dysfunction in multiple sclerosis (MS), particularly in its progressive form (PMS), using a mouse model.
- It compares the effects of traditional immunosuppressants (dexamethasone and fingolimod) with mTOR inhibitors (rapamycin and everolimus), finding that mTOR inhibitors significantly delayed disease progression and extended survival in mice.
- The research highlights the importance of enhancing mitochondrial function as a promising therapeutic approach for PMS, suggesting that mTOR inhibitors could be beneficial in treating this condition.