Publications by authors named "D Guasco"
Bone marrow monocytes are primarily committed to osteoclast formation. It is, however, unknown whether potential primary alterations are specifically present in bone marrow monocytes from patients with multiple myeloma, smoldering myeloma or monoclonal gammopathy of undetermined significance. We analyzed the immunophenotypic and transcriptional profiles of bone marrow CD14 monocytes in a cohort of patients with different types of monoclonal gammopathies to identify alterations involved in myeloma-enhanced osteoclastogenesis.
View Article and Find Full Text PDFGalectin-1 (Gal-1) is involved in tumoral angiogenesis, hypoxia and metastases. Actually the Gal-1 expression profile in multiple myeloma (MM) patients and its pathophysiological role in MM-induced angiogenesis and tumoral growth are unknown. In this study, we found that Gal-1 expression by MM cells was upregulated in hypoxic conditions and that stable knockdown of hypoxia inducible factor-1α significantly downregulated its expression.
View Article and Find Full Text PDFArticle Synopsis
- The study examined 455 multiple myeloma patients to understand the link between bone marrow cytokine/chemokine levels, cytogenetic profiles, and skeletal disease involvement.
- Significantly elevated levels of CCL3 and CCL20 in the bone marrow were found in MM patients with osteolytic lesions and those with positive PET/CT scans.
- The findings suggest that CCL20 levels are strong predictors of bone damage seen in X-rays, while DKK-1 is associated with MRI lesions, emphasizing the connection between these biomarkers and myeloma bone disease.