Publications by authors named "D Grosset"
Article Synopsis
- - Up to 80% of patients with Parkinson's disease experience dementia, but the timing varies widely, and the relationship between Parkinson's disease dementia and dementia with Lewy bodies is still debated.
- - A study analyzed genetic data from 7804 patients to investigate how genetic factors influence the development of dementia in Lewy body diseases, revealing certain risk and protective alleles.
- - Key findings include the identification of the risk allele rs429358, which increases the odds of developing dementia, and protective alleles near specific genes that may help prevent it, highlighting the need for further research with confirmed cases.
Background: Dopaminergic responsiveness is a defining feature of Parkinson's disease (PD). However, there is limited information on how this evolves over time.
Objectives: To examine serial dopaminergic responses, if there are distinct patterns, and which factors predict these.
Article Synopsis
- * A study involving 6,766 PD patients over several years examined how genetic factors influence motor progression and mortality, revealing the APOE ε4 allele as significantly impacting mortality rates.
- * Four new genetic loci were identified, linked to motor progression, suggesting potential targets for future treatment strategies in PD, although further investigation is necessary to understand their biological implications.
Background: Motor complications are well recognized in Parkinson's disease (PD), but their reported prevalence varies and functional impact has not been well studied.
Objectives: To quantify the presence, severity, impact and associated factors for motor complications in PD.
Methods: Analysis of three large prospective cohort studies of recent-onset PD patients followed for up to 12 years.
Bi-allelic pathogenic variants in PRKN are the most common cause of autosomal recessive Parkinson's disease (PD). 647 patients with PRKN-PD were included in this international study. The pathogenic variants present were characterised and investigated for their effect on phenotype.
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