Endoscopic En Bloc Versus Piecemeal Resection of Large Colonic Adenomas: carbon footprint post-hoc analysis of a randomized trial.

Background And Aims: Endoscopy makes a significant contribution to the carbon footprint of healthcare. A randomized trial (RESECT-COLON) demonstrated that Endoscopic Submucosal Dissection (ESD) decreases the recurrence rate of large adenomas (>25 mm) versus piecemeal Endoscopic Mucosal Resection (P-EMR), reducing the need for follow-up colonoscopy. We aimed to compare the carbon footprint of those 2 strategies.

Identifying rare variants in genes related to bone phenotypes in a cohort of postmenopausal women.

Unlabelled: Rare genetic variants in genes previously described to be involved in bone monogenic disorders were identified in postmenopausal women split into two groups according to extreme bone mineral density (BMD) values and lumbar spine Z-scores. A pathogenic variant in COL1A2 gene found in a woman with low BMD highlights the overlap between osteogenesis imperfecta and osteoporosis, which may share their genetic etiology. Other variants were not clearly associated with the extreme BMD, suggesting that there is little contribution of rare variants to postmenopausal osteoporosis.

Assessing the contribution of genes involved in monogenic bone disorders to the etiology of atypical femoral fractures.

Background: Recent studies suggested that genetic variants associated with monogenic bone disorders were involved in the pathogenesis of atypical femoral fractures (AFF). Here, we aim to identify rare genetic variants by whole exome sequencing in genes involved in monogenic rare skeletal diseases in 12 women with AFF and 4 controls without any fracture.

Results: Out of 33 genetic variants identified in women with AFF, eleven (33.

Environmental impact of single-use versus reusable gastroscopes.

Introduction: The environmental impact of endoscopy is a topic of growing interest. This study aimed to compare the carbon footprint of performing an esogastroduodenoscopy (EGD) with a reusable (RU) or with a single-use (SU) disposable gastroscope.

Methods: SU (Ambu aScope Gastro) and RU gastroscopes (Olympus, H190) were evaluated using life cycle assessment methodology (ISO 14040) including the manufacture, distribution, usage, reprocessing and disposal of the endoscope.