Publications by authors named "D Grieco"
Introduction: During mitosis, chromosome alignment at the mitotic spindle equator grants correct chromosome segregation and proper nuclei formation in daughter cells. The kinesin 8 family member Kif18A plays a crucial role for chromosome alignment by localizing at the kinetochore-microtubule (K-MT) plus ends to dampen MT dynamics and stabilize K-MT attachments. Kif18A action is directly antagonized by the master mitotic kinase cyclin B-dependent kinase 1 (Cdk1) and is promoted by protein phosphatase 1 (PP1).
View Article and Find Full Text PDFPurpose: The optimal physiologic parameters to monitor after a session of awake prone positioning in patients with acute respiratory failure are not well understood. This study aimed to identify which early physiologic changes after the first session of awake prone positioning are linked to the need for invasive mechanical ventilation or death in patients with acute respiratory failure.
Methods: We performed a secondary analysis of a prospective cohort study of adult patients with acute respiratory failure related to coronavirus disease 2019 (COVID-19) treated with awake prone positioning.
Article Synopsis
- The study aimed to compare the effects of personalized positive end-expiratory pressure (PEEP) versus a standard low PEEP/FiO2 table on patients with acute respiratory distress syndrome (ARDS) undergoing pressure support ventilation (PSV).
- Researchers conducted a cross-over randomized trial with 30 ARDS patients, measuring how different PEEP settings affected lung mechanics and patient comfort.
- Results showed that the personalized PEEP significantly improved lung function, reduced respiratory effort, and did not lead to lung overdistension, making it a promising approach for treating ARDS during ventilation.
Article Synopsis
- Acute hypercapnic respiratory failure is a serious condition primarily caused by insufficient breathing, often linked to chronic obstructive pulmonary disease and muscle dysfunction.
- Noninvasive ventilation using a mask is the preferred first-line treatment to improve patient survival and outcomes, while high-flow nasal oxygen is considered a supportive option, although it has a higher failure rate compared to noninvasive ventilation.
- The review discusses optimal settings for high-flow nasal oxygen and highlights its potential benefits when used after noninvasive ventilation or during weaning from mechanical ventilation.
Article Synopsis
- Colistin, specifically colistimethate (CMS), is still used in critically ill patients, particularly those on continuous renal replacement therapy (CRRT) for infections caused by carbapenem-resistant bacteria, despite limited real-life data on its effectiveness and safety.
- A study involving 20 critically ill patients receiving a specific dosage of CMS showed high colistin levels in their blood but raised concerns about exceeding safety limits, as many patients experienced poor outcomes including a high mortality rate.
- The findings suggest that while the recommended dosing achieves effective concentrations against bacteria, it poses risks of toxicity, and close monitoring is necessary to balance efficacy and safety.