Epigenetic regulation in colorectal cancer: The susceptibility of microRNAs 145, 143 and 133b to DNA demethylation and histone deacetylase inhibitors.

Globally, colorectal cancer (CRC) is a major health concern. Despite improvements in CRC treatment, mortality rates remain high. Genetic instability and epigenetic dysregulation of gene expression are instigators of CRC development that result in genotypic differences, leading to often variable and unpredictable treatment responses.

Evaluation of Access Disparities to Biologic Disease-Modifying Antirheumatic Drugs in Rural and Urban Communities.

The American College of Rheumatology guidelines provides a strong recommendation for the use of biologic disease-modifying antirheumatic drugs (bDMARDs) when conventional rheumatoid arthritis treatments fail to meet treatment targets. Although bDMARDs are an effective and important treatment component, access inequalities remain a challenge in many communities worldwide. The purpose of this analysis is to assess nationwide trends in bDMARD access in the United States, with a specific focus on rural and urban access gaps.

Display lag and gain effects on vection experienced by active observers.

Background: This study examined the effects of display lag and gain on visual self-motion perception (i.e., vection) in active observers.

Depth interval estimates from motion parallax and binocular disparity beyond interaction space.

Static and dynamic observers provided binocular and monocular estimates of the depths between real objects lying well beyond interaction space. On each trial, pairs of LEDs were presented inside a dark railway tunnel. The nearest LED was always 40 m from the observer, with the depth separation between LED pairs ranging from 0 up to 248 m.

Stereoscopic perception of real depths at large distances.

There has been no direct examination of stereoscopic depth perception at very large observation distances and depths. We measured perceptions of depth magnitude at distances where it is frequently reported without evidence that stereopsis is non-functional. We adapted methods pioneered at distances up to 9 m by R.