Insulin sensitivity in Familial Multiple Lipomatosis.

Background: Familial Multiple Lipomatosis (FML) is a mainly autosomal dominant rare benign condition. Excessive fat storage (obesity), as well as the inability to store fat (lipodystrophy), is associated with insulin resistance.

Aim: Our study aimed to document if also patients affected by regional excess of subcutaneous adipose tissue as in FML show this feature.

Underestimation of urinary albumin to creatinine ratio in morbidly obese subjects due to high urinary creatinine excretion.

Background & Aims: Albuminuria, a chronic kidney and/or cardiovascular disease biomarker, is currently measured as albumin-to-creatinine ratio (ACR). We hypothesize that in severely obese individuals ACR might be abnormally low in spite of relatively high levels of urinary albumin due to increased creatininuria.

Methods: One-hundred-eighty-four subjects were divided into tertiles based on their BMI.