Publications by authors named "D Gnatta"
Background: Antimicrobials are widely used in hospitals and are often associated with adverse drug reactions (ADRs). The objective of this study was to determine the incidence of ADRs caused by antimicrobials and classify them according to the type of reaction, the class of antimicrobials used, causality, severity and avoidability.
Methods: A prospective cohort study was carried out with paediatric patients for 6 months.
Article Synopsis
- This study investigates the effects of converting hepatitis C-positive kidney transplant recipients to everolimus (EVR) as there is no established immunosuppressive protocol for this group.
- Participants were randomly assigned to either switch to EVR or continue with calcineurin inhibitors, with a total of 30 patients involved, and 28 followed up for one year.
- Results indicated that while viral loads remained stable across both groups, those on EVR experienced higher rates of dyslipidemia and proteinuria, with no significant changes in kidney function or other complications.
Article Synopsis
- The study evaluates the use of dried blood spots (DBS) for measuring mycophenolic acid (MPA) in kidney transplant patients, comparing it to traditional plasma sampling.
- Data was collected from 19 patients, analyzing 77 paired samples using high-performance liquid chromatography (HPLC) to measure MPA levels in both DBS and plasma.
- Results showed a strong correlation between DBS and plasma measurements, indicating that DBS is a viable option for therapeutic drug monitoring in clinical settings, especially in resource-limited areas.
Small children are a challenging group in whom to perform KT. This retrospective study analyzed the results of 62 KTs in children weighing <15 kg, performed between 1998 and 2010, using extraperitoneal access and anastomosis of the renal vessels of donors to the aorta and IVC or iliac vessels of the recipients. Thirty-two (51.
View Article and Find Full Text PDFIntroduction: Posttransplant diabetes mellitus (PTDM) is considered to be a serious complication of kidney transplantation that may reduce patient and graft survival. The immunosuppressant tacrolimus (TAC) increases the risk of developing PTDM.
Purpose: We sought to estimate the risk of PTDM among renal transplant recipients treated with TAC, to identify other risk factors for PTDM, and to describe its consequences.