Publications by authors named "D Giudici"
Background And Objectives: Covert brain infarcts (CBIs) in patients with first-ever ischemic stroke (IS) and atrial fibrillation (AF) are associated with an increased risk of stroke recurrence. We aimed to assess whether CBIs modify the treatment effect of early vs late initiation of direct oral anticoagulants (DOACs) in patients with IS and AF.
Methods: We conducted a post hoc analysis of the international, multicenter, randomized-controlled ELAN trial, which compared early (<48 hours after ischemic stroke for minor and moderate stroke, 6-7 days for major stroke) vs late (>48 hours for minor, 3-4 days for moderate, 12-14 days for major stroke) initiation of DOACs in patients with IS and AF.
Background: The effect of early as compared with later initiation of direct oral anticoagulants (DOACs) in persons with atrial fibrillation who have had an acute ischemic stroke is unclear.
Methods: We performed an investigator-initiated, open-label trial at 103 sites in 15 countries. Participants were randomly assigned in a 1:1 ratio to early anticoagulation (within 48 hours after a minor or moderate stroke or on day 6 or 7 after a major stroke) or later anticoagulation (day 3 or 4 after a minor stroke, day 6 or 7 after a moderate stroke, or day 12, 13, or 14 after a major stroke).
Epidemiology of nosocomial infection in 125 Italian intensive care units.
Minerva Anestesiol
January 2010
Aim: A continuous infection surveillance program was conducted by GiViTI throughout 2006 in Intensive Care Units (ICUs).
Methods: This was a prospective epidemiological study carried out in 125 Italian intensive care units. All patients have been included in the study.
The aims of the study were to analyze the clinical and epidemiological characteristics and treatments for patients who developed zygomycosis enrolled in Italy during the European Confederation of Medical Mycology of medical mycology survey. This prospective multicenter study was performed between 2004 and 2007 at 49 italian Departments. 60 cases of zygomycosis were enrolled: the median age was 59.
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- Study involved data collection from 71 ICUs in Italy over 6 months to understand infection rates among patients, both at admission and acquired during their stay.
- Of 9,493 patients, 11.6% had a community-acquired infection, 7.4% a hospital-acquired infection, and 11.4% an ICU-acquired infection, with higher mortality rates for those admitted with infections.
- The study suggests improving the treatment of severe sepsis and septic shock to reduce ICU-related mortality, highlighting the importance of targeted infection prevention and surveillance programs.