Publications by authors named "D Girard"
Why severe injury to the central nervous system (CNS) triggers the development of large neurogenic heterotopic ossifications (NHOs) within periarticular muscles remains unknown. We report that spinal cord injury (SCI) triggers a rapid corticosterone spike in mice, which is causal for NHO development because treatments with corticosterone or the synthetic glucocorticoid (GC) receptor (GR) agonist dexamethasone are sufficient to trigger heterotopic ossification and upregulate the expression of osteoinductive and osteogenic differentiation genes in injured muscles even without SCI. The central role for GR signaling in causing NHO is further demonstrated in mice deleted for the GR gene (Nr3c1), which no longer develop NHO after SCI.
View Article and Find Full Text PDFArticle Synopsis
- Diagnosing infectious diseases is complicated, and this study aimed to analyze diagnostic uncertainty (DU) in patients with positive blood cultures (PBC) and assess how it affects antibiotic treatment and patient outcomes.
- The research involved real-time communication of PBC results to infectious disease specialists, who reviewed patient charts and provided treatment advice, highlighting that 47% of cases experienced diagnostic uncertainty.
- Findings indicated that DU was linked to higher hospitalization rates, increased use of broad-spectrum antibiotics, and a greater likelihood of poor outcomes, including death during hospitalization.
Dye-based fluorescent organic nanoparticles are a specific class of nanoparticles obtained by nanoprecipitation in water of pure dyes only. While the photophysical and colloidal properties of the nanoparticles strongly depend on the nature of the aggregated dyes, their excellent brightness in the visible and in the near infrared make these nanoparticles a unique and versatile platform for in vivo application. This article examines the promising utilization of these nanoparticles for in vivo optogenetics applications.
View Article and Find Full Text PDFLicensed nonmedical, skin-aware professionals (e.g., hairdressers, massage therapists, etc.
View Article and Find Full Text PDFAims: To systematically appraise and summarise meta-analyses of longitudinal studies to determine the effect size, and quality and certainty of the evidence summaries for systolic blood pressure (SBP), serum cholesterol, and physical activity behaviour in developing cardiovascular disease (CVD).
Methods And Results: An umbrella review was conducted by searching MEDLINE, Embase, and Scopus databases. Eligible meta-analyses were longitudinal studies investigating the association between SBP, serum cholesterol, or physical activity behaviour on CVD development.