Publications by authors named "D Ginestet"

The quality of life concept has been increasingly used as a major tool for patient care and clinical investigations. The Heinrichs quality of life scale (QLS) is the quality of life assessment method widely used in schizophrenic patients. The QLS was translated into its French version by J.

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ANTIPSYCHOTIC PROPERTIES: Compared with traditional neuroleptics, antipsychotics affect receptors other than dopaminergic receptors, particularly serotonin receptors. Clinically, antipsychotics have little or no extrapyramidal effects and do not induce late dyskinesia. They are effective for productive symptoms.

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The efficacy of tianeptine in the treatment of major depressive episodes was assessed in three double-blind placebo-controlled studies. In a first double-blind study comparing tianeptine (37.5 mg/day) with placebo, 126 patients with Major Depression or a Depressed Bipolar Disorder were treated for 42 days; 60% of these patients fulfilled DSM-III-R criteria for melancholia.

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The association of major depressive disorders with personality disorders is relevant in terms of clinical, therapeutic and prognostic aspects. However, the prevalence of this association remains unclear. This may be due to methodological considerations.

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In a retrospective study of 133 in-patients with a major depressive disorder, we first described the associated psychiatric (axis I and axis II) or somatic diseases (axis III). Then, we described the patients and therapeutical practices related to comorbidity. The results of this study showed that comorbidity concerned 89% of the patients.

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