Publications by authors named "D Ghinolfi"
: The rising use of liver grafts from donation after circulatory death (DCD) has been enabled by advances in normothermic regional perfusion (NRP) and machine perfusion (MP) technologies. We aimed to identify predictive biomarkers in DCD grafts subjected to NRP, followed by randomization to either normothermic machine perfusion (NMP) or dual hypothermic oxygenated perfusion (D-HOPE). : Among 57 DCD donors, 32 liver grafts were transplanted, and recipients were monitored for one week post-transplant.
View Article and Find Full Text PDFBackground: Cardiovascular events represent a major cause of non-graft-related death after liver transplant. Evidence suggest that chronic inflammation associated with a remarkable oxidative stress in the presence of endothelial dysfunction and procoagulant environment plays a major role in the promotion of thrombosis. However, the underlying molecular mechanisms are not completely understood.
View Article and Find Full Text PDFDual hypothermic oxygenated perfusion (DHOPE) is increasingly being used to extend liver preservation to improve transplant logistics. However, little is known about its benefits in high-risk liver grafts. This study aimed to investigate whether prolonged DHOPE provides benefits other than improved logistics in all liver types.
View Article and Find Full Text PDFBackground: The challenge of transplant waiting-lists is to provide organs for all candidates while maintaining efficiency and equity.
Aims: We investigated the probability of being transplanted or of waiting-list dropout in Italy.
Methods: Data from 12,749 adult patients waitlisted for primary liver-transplantation from January 2012 to December 2022 were collected from the National Transplant-Registry.
Article Synopsis
- Liver transplantation (LT) was once thought not to work for a type of cancer called perihilar cholangiocarcinoma (pCCA), but a new method from the Mayo Clinic showed it could help if patients followed strict rules and took certain treatments first.
- In a study of 22 liver transplant centers in Italy, 53 patients with pCCA were looked at, with some getting special treatment before the transplant and others not.
- The results showed that patients who had the pre-treatment did better after 1, 3, and 5 years compared to those who didn’t, leading to talks about making new rules for how to treat this cancer better in Italy.