Recruitment, retention and reporting of variables related to ethnic diversity in randomised controlled trials: an umbrella review.

Objective: This umbrella review synthesises evidence on the methods used to recruit and retain ethnically diverse participants and report and analyse variables related to ethnic diversity in randomised controlled trials.

Design: Umbrella review.

Data Sources: Ovid MEDLINE, Ovid Embase, CINAHL, PsycINFO and Cochrane and Campbell Libraries for review papers published between 1 January 2010 and 13 May 2024.

Computational Methods for Predicting Key Interactions in T Cell-Mediated Adaptive Immunity.

The adaptive immune system recognizes pathogen- and cancer-specific features and is endowed with memory, enabling it to respond quickly and efficiently to repeated encounters with the same antigens. T cells play a central role in the adaptive immune system by directly targeting intracellular pathogens and helping to activate B cells to secrete antibodies. Several fundamental protein interactions-including those between major histocompatibility complex (MHC) proteins and antigen-derived peptides as well as between T cell receptors and peptide-MHC complexes-underlie the ability of T cells to recognize antigens with great precision.

"We are not invited": Australian focus group results on how to improve ethnic diversity in trials.

Objectives: Lack of ethnic diversity in trials may contribute to health disparities and to inequity in health outcomes. The primary objective was to investigate the experiences and perspectives of ethnically diverse populations about how to improve ethnic diversity in trials.

Study Design And Setting: Qualitative data were collected via 16 focus groups with participants from 21 ethnically diverse communities in Australia.

Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic options and expensive/burdensome drug discovery processes. Utilizing genomic-data-driven Connectivity Mapping (CMAP) to identify a drug closer to real-world PC targeting may improve pancreatic cancer (PC) patient outcomes. Initially, we mapped CMAP data to gene expression from 106 PC patients, identifying nine negatively connected drugs.

Modeling preferential attraction to infected hosts in vector-borne diseases.

Vector-borne infectious diseases cause more than 700,000 deaths a year and represent an increasing threat to public health worldwide. Strategies to mitigate the spread of vector-borne diseases can benefit from a thorough understanding of all mechanisms that contribute to viral propagation in human. A recent study showed that mosquitoes (the vectors for dengue and Zika virus, among others) are preferentially attracted to infected hosts.