Publications by authors named "D Gervasoni"
Article Synopsis
- Techniques of stereotaxic surgery are widely used in research labs to enhance studies while adhering to international laws and 3R principles (replacement, reduction, refinement) to minimize animal suffering.
- The report highlights improvements in neurosurgical techniques developed over decades which have notably decreased the number of rats used and enhanced their recovery experience post-surgery.
- Detailed descriptions of pre-, per-, and post-surgical procedures cover anesthesia management, stereotaxic coordination, and targeting methods, promoting ethical research practices that align with European animal welfare regulations.
Article Synopsis
- Modern neuroscience often involves recording local field potentials (LFPs) from moving animals, with wireless transmission eliminating the need for cumbersome wires, but it faces challenges due to high data transmission rates.
- To address this, a new encoder/decoder scheme based on adaptive non-uniform quantization is proposed, which dynamically adjusts quantization intervals based on the changing statistics of LFP signals, allowing for efficient real-time data transmission without needing extra side information.
- The development of an open-source neural recording device called NeRD shows promising results, as it can effectively transmit LFPs from freely moving rats while being small, lightweight, and power-efficient, thus enabling practical use in the field of neuroscience.
The present study is aimed at describing some aspects of the neural dynamics supporting discrimination of olfactory-tactile paired-associated stimuli during acquisition of new pairs and during recombination of previously learned pairs in the rat. To solve the task, animals have to identify one odor-texture (OT) combination associated with a food reward among three cups with overlapping elements. Previous experiments demonstrated that the lateral entorhinal cortex (LEC) is involved in the processes underlying OT acquisition, whereas the dorsal hippocampus (DH) is selectively involved in the recombination processes.
View Article and Find Full Text PDFStudy Objective: This study was designed to evaluate an unsupervised adaptive algorithm for real-time detection of sleep and wake states in rodents.
Design: We designed a Bayesian classifier that automatically extracts electroencephalogram (EEG) and electromyogram (EMG) features and categorizes non-overlapping 5-s epochs into one of the three major sleep and wake states without any human supervision. This sleep-scoring algorithm is coupled online with a new device to perform selective paradoxical sleep deprivation (PSD).
Histamine receptor type 3 (H3) antagonists are promising awakening drugs for treatment of sleep disorders. However, few works have tried to identify their cognitive effects after sleep restriction and their impact on associated neural networks. To that aim, Bl/6J male mice were submitted to acute sleep restriction in a shaker apparatus that prevents sleep by transient (20-40 ms) up and down movements.
View Article and Find Full Text PDF