Publications by authors named "D Gerecke"
Article Synopsis
- Amino-Plex (SM1997) is a cosmeceutical spray designed to treat skin dryness and aging by containing electrolytes, amino acids, and other beneficial compounds.
- It aims to enhance cell repair by increasing oxygen levels, improving glucose transport, and stimulating collagen synthesis, which helps in healing damaged skin.
- Recent tests show that SM1997 helps retain corneal epithelial attachment and reduces enzyme activation that causes damage after exposure to mustard gas, indicating its potential for further research in treating such injuries.
Sulfur mustard (SM) is a highly toxic blistering agent thought to mediate its action, in part, by activating matrix metalloproteinases (MMPs) in the skin and disrupting components of the basement membrane zone (BMZ). Type IV collagenases (MMP-9) degrade type IV collagen in the skin, a major component of the BMZ at the dermal-epidermal junction. In the present studies, a type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), was tested for its ability to protect the skin against injury induced by SM in the mouse ear vesicant model.
View Article and Find Full Text PDFLaminin-332 is a basement membrane protein composed of three genetically distinct polypeptide chains that actively promote both skin epidermal cell adhesion and migration. Proteolytic fragments of the laminin γ2 chain stimulate migration and scattering of keratinocytes and cancer cells. Sulfur mustard (SM) is a bifunctional alkylating agent that induces separation of basal keratinocytes from the dermal-epidermal junction and invokes a strong inflammatory response leading to delayed wound repair.
View Article and Find Full Text PDFExpression of Laminin 332 in Vesicant Skin Injury and Wound Repair.
Clin Dermatol (Wilmington)
January 2018
Sulfur Mustard (SM) is a potent vesicant or blistering agent. It is a highly reactive bi-functional alkylating agent that cross links proteins, DNA, and other cellular components. Laminin 332 is a heterotrimer glycoprotein and a crucial skin component that attaches the epidermal basal keratinocytes to the dermis.
View Article and Find Full Text PDFExpression of cytokines and chemokines in mouse skin treated with sulfur mustard.
Toxicol Appl Pharmacol
September 2018
Article Synopsis
- Sulfur mustard (SM) is a chemical warfare agent that causes severe skin damage, leading to inflammation, blisters, and tissue destruction as seen in mouse ear studies.
- The research revealed that exposure to SM results in increased accumulation of immune cells (macrophages and neutrophils) in the skin, along with significant rises in inflammatory cytokines like interleukin and tumor necrosis factor over at least a week.
- The study highlights the role of these inflammatory mediators in worsening skin injury from SM, suggesting that targeting the inflammatory response could help treat or lessen the damage caused by this chemical agent.