Publications by authors named "D Geraghty"
Aims/hypothesis: The aim of this work was to explore molecular amino acids (AAs) and related structures of HLA-DQA1-DQB1 that underlie its contribution to the progression from stages 1 or 2 to stage 3 type 1 diabetes.
Methods: Using high-resolution DQA1 and DQB1 genotypes from 1216 participants in the Diabetes Prevention Trial-Type 1 and the Diabetes Prevention Trial, we applied hierarchically organised haplotype association analysis (HOH) to decipher which AAs contributed to the associations of DQ with disease and their structural properties. HOH relied on the Cox regression to quantify the association of DQ with time-to-onset of type 1 diabetes.
Chimerism analysis by next-generation sequencing (NGS) is an emerging method for engraftment monitoring after allogeneic hematopoietic cell transplantation. A high-sensitivity method is required for the detection of microchimerism (<1% chimerism), which may have clinical utility in early relapse detection, allograft monitoring in organ transplantation, and other allogeneic cellular therapies (such as microtransplantations). As more clinical laboratories adopt this method, a thorough assessment of performance is needed.
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- Plasmodium falciparum's RH5 protein is a promising candidate for a malaria vaccine, and understanding the antibody response during natural infections is crucial for optimizing vaccine efficacy.
- Researchers found that B cells reacting to RH5 were uncommon, and the IgG responses in malaria-exposed individuals were short-lived despite multiple infections.
- Some antibodies from malaria-exposed individuals showed strong neutralizing ability and targeted similar sites as the most effective vaccine-induced antibodies, indicating that natural infections might enhance the effectiveness of RH5 vaccines in the future.
Article Synopsis
- The study aimed to investigate whether oral insulin can postpone the onset of stage 3 type 1 diabetes (T1D) in patients who have stage 1 or 2 T1D and specific genetic markers (HLA DR4-DQ8) or elevated IA-2 autoantibodies.
- Researchers used advanced genetic testing on 546 participants to analyze the connection between genetic factors and autoantibody levels prior to treatment, utilizing Cox regression to assess the effectiveness of oral insulin.
- Findings revealed that oral insulin significantly decreased the T1D onset in participants with high IA-2A levels, particularly among those carrying the HLA DR4-DQ8 haplotype, indicating a specific endotype of T1D
Article Synopsis
- The study aimed to understand different recovery patterns in neurocognitive function after pediatric concussions over three months and identify factors that influence recovery trajectories.
- Researchers analyzed data from 74 kids aged 8-17 and found three distinct recovery groups: two groups showed improvement in information processing, while one group had minimal change and lower scores on cognitive tests.
- The findings highlighted that a previous history of headaches was linked to the group with the least improvement, suggesting that pre-existing conditions could help identify children who may need more support after a concussion.