The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of mitiperstat.

Aims: Mitiperstat is a novel, highly potent myeloperoxidase inhibitor being evaluated in patients with cardio-metabolic disease (phase 2). These patients often have impaired renal function, which may affect mitiperstat pharmacokinetics. This study assessed mitiperstat pharmacokinetics, safety and tolerability in participants with severe renal impairment and normal renal function, to inform inclusion of participants with estimated glomerular filtration rate (eGFR) < 30 mL/min/1.

Surface plasmon enhanced fluorescence: self-consistent classical treatment in the quasi-static limit.

The problem of enhanced molecular emission in close proximity to dielectric and metallic interfaces is of great importance for many physical and biological applications. Here we present an exact treatment of the problem from the view point of classical electromagnetism. Self-consistent analytical theory of the surface enhanced fluorescence (SEF) is developed for configurations consisting of an emitter in proximity to core-shell metal-dielectric nanoparticles.

Effect of KBP-5074 on Blood Pressure in Advanced Chronic Kidney Disease: Results of the BLOCK-CKD Study.

[Figure: see text].

Active Control of Charge Density Waves at Degenerate Semiconductor Interfaces.

We present an optoelectronic switch for functional plasmonic circuits based on active control of Surface Plasmon Polaritons (SPPs) at degenerate PN-junction interfaces. Self-consistent multi-physics simulations of the electromagnetic, thermal and IV characteristics of the device have been performed. The lattice matched Indium Gallium Arsenide (InGaAs) is identified as a better semiconductor material compared to Si for the practical implementation of the proposed optoelectronic switch providing higher optical confinement, reduced size and faster operation.

Omnidirectional optical attractor in structured gap-surface plasmon waveguide.

An optical attractor based on a simple and easy to fabricate structured metal-dielectric-metal (SMDM) waveguide is proposed. The structured waveguide has a variable thickness in the vicinity of an embedded microsphere and allow for adiabatic nano-focusing of gap-surface plasmon polaritons (GSPPs). We show that the proposed system acts as an omnidirectional absorber across a broad spectral range.