Automated Fast Prediction of Bone Mineral Density From Low-dose Computed Tomography.

Background: Low-dose chest CT (LDCT) is commonly employed for the early screening of lung cancer. However, it has rarely been utilized in the assessment of volumetric bone mineral density (vBMD) and the diagnosis of osteoporosis (OP).

Purpose: This study investigated the feasibility of using deep learning to establish a system for vBMD prediction and OP classification based on LDCT scans.

Intensive Blood Pressure Strategy on Cardiovascular Diseases in Patients With Metabolic Syndrome: Post Hoc Analysis of a Clinical Trial.

Background: Blood pressure (BP) management in patients with metabolic syndrome is complex, and optimal targets remain debated. The CRHCP (China Rural Hypertension Control Project) trial demonstrated that intensive BP control reduces cardiovascular events. This secondary analysis assessed its efficacy in patients with hypertension and metabolic syndrome.

Viscoelastic Hydrogel Promotes Disc Mechanical Homeostasis Repair and Delays Intervertebral Disc Degeneration via the Yes-Associated Protein Pathway.

Intervertebral disc degeneration (IDD) process is accompanied by overactive inflammation and mechanical instability of the nucleus pulposus (NP). Current treatments do not fully restore the biomechanical environment of discs, limiting their therapeutic efficacy. Thus, novel strategies are required to combat IDD.

Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration.

Osteoporotic bone regeneration poses significant challenges due to the complexity of the condition. Osteoporosis, a degenerative disorder, results from an imbalance in bone homeostasis driven by dysregulation of osteoblast and osteoclast activity. This complicates the treatment of osteoporosis and its related bone injuries in clinical practice.

Unravelling the structure-stability interplay of O3-type layered sodium cathode materials via precision spacing engineering.

The O3-type layered oxide represents a highly promising candidate for sodium-ion batteries (SIBs). However, the intrinsic stability law of these cathodes remains elusive due to the complex phase transition mechanism and migration of transition metal (TM) ions. Here, we underscore how the ratio between the spacings of alkali metal layer and TM layer (R = d/d) plays a critical role in determining the structural stability and the corresponding electrochemical performance.