Publications by authors named "D Geetha"
Therapeutic plasma exchange (PLEX) is an adjunctive treatment for patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and kidney involvement. Little is known about the effect of PLEX on early changes in kidney function. This post-hoc analysis of the PEXIVAS trial investigated the effects of PLEX on changes in kidney function within 12 months.
View Article and Find Full Text PDFRapidly progressive glomerulonephritis (RPGN) is a syndrome characterized by a swift decline in kidney function, often over a few months, accompanied by features of nephritic syndrome. It can result in decreased urine output and commonly involves the presence of extensive crescents in kidney biopsies. RPGN is classified into 3 main types based on immune deposit distribution and visualization through immunofluorescence and electron microscopy: antiglomerular basement membrane disease, immune complex glomerulonephritis, and pauci-immune glomerulonephritis.
View Article and Find Full Text PDFArticle Synopsis
- - Focal Segmental Glomerulosclerosis (FSGS) is a complex kidney disorder that leads to nephrotic syndrome and can cause kidney failure in both children and adults.
- - The Kidney Health Initiative is exploring the potential of using proteinuria (excess protein in urine) as a key indicator for measuring treatment outcomes in FSGS clinical trials.
- - While total remission of proteinuria seems to correlate strongly with better kidney health, more research is necessary to establish how to best evaluate treatment effects, with ongoing efforts to consolidate data from various studies.
Article Synopsis
- The study focuses on the risk of pneumonia (PJP) in patients with ANCA-associated vasculitis (AAV) undergoing maintenance therapy with rituximab, aiming to assess the effectiveness of PJP prophylaxis.
- It involved an observational analysis of 129 AAV patients, where 44% received PJP prophylaxis, but no PJP infections were reported in the group, regardless of prophylaxis status.
- Additionally, factors such as lung involvement increased the likelihood of receiving prophylaxis, while glucocorticoid use led to higher rates of hospitalizations and deaths, highlighting the need for careful management of these patients.