Publications by authors named "D Gawlitta"
Article Synopsis
- * Additive manufacturing allows for the creation of customizable 3D biomaterial scaffolds that promote bone formation through guiding cell activities and can degrade as new bone tissue forms, making them suitable for use as synthetic grafts.
- * This review discusses advancements in bioceramic grafts created by 3D printing, including details on material properties, fabrication techniques, and the biological responses of these materials, while also summarizing their clinical applications and potential for personalized craniomaxillofacial bone
Article Synopsis
- - Emerging research highlights that osteoclasts (OCs) have important roles in both bone formation and regeneration, beyond their traditional function of bone resorption, but their lifecycle and characteristics are still not fully understood.
- - Osteoclasts originate from osteoclast precursors (OCPs) derived from erythromyeloid progenitors (EMPs) during embryonic development and shift to being primarily sourced from hematopoietic stem cells (HSCs) postnatally, with their absence leading to serious bone structure issues.
- - The paper also discusses the challenges in isolating pure OC cultures and understanding their in vivo functions, as they interact closely with the immune system and blood vessels, and it offers insights into OCP
Autologous bone grafts are commonly used to repair defects in skeletal tissue, however, due to their limited supply there is a clinical need for alternatives. Synthetic ceramics present a promising option but currently lack biological activity to stimulate bone regeneration. One potential approach to address this limitation is the incorporation of immunomodulatory agents.
View Article and Find Full Text PDFEndochondral bone regeneration is a promising approach in regenerative medicine. Callus mimics (CMs) are engineered and remodeled into bone tissue upon implantation. The long-term objective is to fabricate a sustainable off-the-shelf treatment option for patients.
View Article and Find Full Text PDFMacrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts occur during specific immune training of macrophages that affect their functional state, resulting in heightened (trained) or reduced (tolerant) responses upon exposure to a second stimulus. This is known as innate immune memory.
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