Publications by authors named "D Gawande"
Neuropathic pain presents a significant challenge, with its underlying mechanisms still not fully understood. Here, we investigated the role of GluN2C- and GluN2D-containing NMDA receptors in the development of neuropathic pain induced by cisplatin, a widely used chemotherapeutic agent. Through genetic and pharmacological strategies, we found that GluN2D-containing NMDA receptors play a targeted role in regulating cisplatin-induced neuropathic pain (CINP), while sparing inflammatory or acute pain responses.
View Article and Find Full Text PDFCochlear ribbon synapses between sensory inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are vulnerable to rapid and primary damage and/or loss due to noise overexposure. Such damaged ribbon synapses can repair spontaneously in mouse and guinea pig. However, the mechanisms for synaptic repair are unclear.
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- - The study investigates how HIF-1α in astrocytes contributes to the harmful effects of HIV-1 Tat on neurons, particularly related to the formation of amyloids that are linked to Alzheimer's-like symptoms in HIV-Associated Neurocognitive Disorders (HAND).
- - Researchers found that when rat hippocampal neurons are exposed to astrocyte-derived extracellular vesicles (ADEVs) carrying these toxic amyloids, it leads to neuronal damage, including synaptic loss and functional declines in communication between neurons.
- - Silencing HIF-1α in astrocytes reduced the production of amyloid-carrying ADEVs, protecting neurons from damage and preventing related behavioral changes and Alzheimer's-like pathology in mice, suggesting HIF
Thalamic regulation of cortical function is important for several behavioral aspects including attention and sensorimotor control. This region has also been studied for its involvement in seizure activity. Among the NMDA receptor subunits GluN2C and GluN2D are particularly enriched in several thalamic nuclei including nucleus reticularis of the thalamus (nRT).
View Article and Find Full Text PDFBackground: Parvalbumin interneuron (PVI) activity synchronizes the medial prefrontal cortex circuit for normal cognitive function, and its impairment may contribute to schizophrenia (SZ). NMDA receptors in PVIs participate in these activities and form the basis for the NMDA receptor hypofunction hypothesis of SZ. However, the role of the GluN2D subunit, which is enriched in PVIs, in regulating molecular networks relevant to SZ is unknown.
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