Altering prosthetic alignment does not affect hip and low back joint loading during sit-to-stand in people with a transtibial amputation.

People with a transtibial amputation (TTA) have greater prevalence of low back and hip joint pain compared to the general population. Altered movement, loading patterns, and neuromuscular activation during daily tasks like sit-to-stand likely contribute to these high rates of pain. In addition, muscle activation, ground reaction forces, and trunk range of motion can be affected by prosthetic alignment during sit-to-stand.

Enantiopure -Chiral Secondary Phosphines (P*HRR') from the Catalytic Asymmetric Hydrogenation of P═C Bonds.

We report the first bottleable enantiopure -chiral secondary phosphines from the rhodium-catalyzed asymmetric hydrogenation of phosphaalkenes. Catalytic asymmetric hydrogenation, a reaction of broad academic and industrial importance for C═C, N═C, and O═C bonds, has not previously been reported for the P═C bond. The hydrogenation of ArP═CR (Ar = Mes, -Xyl and TMOP; R = Ph, 4-CHF) affords four unprecedented -stereogenic secondary phosphines in 76%-90% isolated yields with 91%-97% enantiomeric excess (ee).

Perspectives on the comparative benefits of body-powered and myoelectric upper limb prostheses.

Background: Patient access to body-powered and myoelectric upper limb prostheses in the United States is often restricted by a healthcare system that prioritizes prosthesis prescription based on cost and perceived value. Although this system operates on an underlying assumption that design differences between these prostheses leads to relative advantages and disadvantages of each device, there is limited empirical evidence to support this view.

Main Text: This commentary article will review a series of studies conducted by our research team with the goal of differentiating how prosthesis design might impact user performance on a variety of interrelated domains.

Comparison of inter-joint coordination strategies during activities of daily living with prosthetic and anatomical limbs.

While healthy individuals have redundant degrees of freedom of the joints, they coordinate their multi-joint movements such that the redundancy is effectively reduced. Achieving high inter-joint coordination may be difficult for upper limb prosthesis users due to the lack of proprioceptive feedback and limited motion of the terminal device. This study compared inter-joint coordination between prosthesis users and individuals without limb loss during different upper limb activities of daily living (ADLs).