Publications by authors named "D Garcia-Calderon"

Despite increasing knowledge about small extracellular vesicle (sEV) composition and functions in cell-cell communication, the mechanism behind their biogenesis remains unclear. Here, we reveal for the first time that sEV biogenesis and release into the microenvironment are tightly connected with another important organelle, Lipid Droplets (LDs). The correlation was observed in several human cancer cell lines as well as patient-derived colorectal cancer stem cells (CR-CSCs).

View Article and Find Full Text PDF
Article Synopsis
  • Gliomas, a severe type of brain tumor, frequently recur and can metastasize, with limited existing treatments for reducing metastasis, highlighting a need for new anti-metastatic agents.
  • Copper complexes have shown potential as effective anti-metastatic agents, but their use may disrupt healthy tissue balance; thus, incorporating these complexes into nano-architectures can enhance targeted delivery and minimize side effects.
  • Newly developed copper complex-loaded nano-architectures (CuLNAs) significantly reduce glioma cell migration without negatively affecting cell growth, and they modulate key genes involved in the epithelial-to-mesenchymal transition, presenting a promising strategy for anticancer therapies.
View Article and Find Full Text PDF

Purpose: Our objective was to develop a methodology for assessing the linear energy transfer (LET) and relative biological effectiveness (RBE) in clinical proton and helium ion beams using fluorescent nuclear track detectors (FNTDs).

Methods And Materials: FNTDs were exposed behind solid water to proton and helium (He) ion spread-out Bragg peaks. Detectors were imaged with a confocal microscope, and the LET spectra were derived from the fluorescence intensity.

View Article and Find Full Text PDF

Background: Minibeam radiation therapy (MBRT) is an innovative dose delivery method with the potential to spare normal tissue while achieving similar tumor control as conventional radiotherapy. However, it is difficult to use a single dose parameter, such as mean dose, to compare different patterns of MBRT due to the spatially fractionated radiation. Also, the mechanism leading to the biological effects is still unknown.

View Article and Find Full Text PDF

Background: Solid tumors are often riddled with hypoxic areas, which develops as a result of high proliferation. Cancer cells willingly adapt and thrive in hypoxia by activating complex changes which contributes to survival and enhanced resistance to treatments, such as photon radiation. Photon radiation primarily relies on oxygen for the production of reactive oxygen species to induce DNA damage.

View Article and Find Full Text PDF