Publications by authors named "D GARCIA TELLEZ"
Background: Histopathological growth patterns are one of the strongest prognostic factors in patients with resected colorectal liver metastases. Development of an efficient, objective and ideally automated histopathological growth pattern scoring method can substantially help the implementation of histopathological growth pattern assessment in daily practice and research. This study aimed to develop and validate a deep-learning algorithm, namely neural image compression, to distinguish desmoplastic from non-desmoplastic histopathological growth patterns of colorectal liver metastases based on digital haematoxylin and eosin-stained slides.
View Article and Find Full Text PDFArticle Synopsis
- * In this study, genetic sequencing was performed on a patient with DC, and their information was compared with leading genetic databases to confirm findings.
- * The authors discovered a new variant of DC and provided 10 practical recommendations for dermatologists and other healthcare professionals to aid in managing patients with this condition.
The tumor microenvironment (TME), composed of and influenced by a heterogeneous set of cancer cells and an extracellular matrix, plays a crucial role in cancer progression. The biophysical aspects of the TME (namely, its architecture and mechanics) regulate interactions and spatial distributions of cancer cells and immune cells. In this review, we discuss the factors of the TME-notably, the extracellular matrix, as well as tumor and stromal cells-that contribute to a pro-tumor, immunosuppressive response.
View Article and Find Full Text PDFImportance: Chronic obstructive pulmonary disease (COPD) is a respiratory condition that is associated with significant health and economic burden worldwide. Previous studies assessed the global current-day prevalence of COPD, but to better facilitate resource planning and intervention development, long-term projections are needed.
Objective: To assess the global burden of COPD through 2050, considering COPD risk factors.
Article Synopsis
- The study examines the relationship between being underweight or obese and negative airway outcomes during tracheal intubation in critically ill children aged 0-17, using data from a national registry between 2013-2020.
- Findings show that underweight (27.5% of patients) and obese (8.2% of patients) children are at a higher risk of experiencing adverse intubation-related events and severe hypoxemia compared to those of normal weight (57.1%).
- It was noted that underweight children are particularly vulnerable, having higher incidences of oxygenation and ventilation failure as the reason for intubation, and they face a greater chance of negative airway outcomes compared to normal weight peers.