Publications by authors named "D G Witte"
To conduct a visual analysis of institutional publications, individual publications and publication keywords in the field of laboratory biosafety using the Web of Science database from 2000 to 2022.VOSviewer 1.6.
View Article and Find Full Text PDFCaregivers are engaging in recreational travel with the neuro-oncology patients they care for, yet there is little scientific research on this phenomenon. The purpose of this study is to examine the experiences of recreational travel among caregiver-patient with brain cancer dyads from the perspective of the caregivers. Specifically, we examined (1) context (i.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the genetic factors influencing β-cell function (BCF) and their relationship to type 2 diabetes (T2D), expanding on previous genetic research using large-scale data.
- By analyzing GWAS data from around 26,000 individuals, the researchers identified 55 unique genetic associations related to BCF traits derived from oral glucose tolerance tests.
- The findings reveal key genes that regulate insulin secretion and illustrate how different genetic mechanisms can affect T2D risk, offering a deeper understanding of the complex biology behind the disease.
Objectives: Here we describe the development and pilot testing of the first artificial intelligence (AI) software "copilot" to help train novices to competently perform flexible fiberoptic laryngoscopy (FFL) on a mannikin and improve their uptake of FFL skills.
Methods: Supervised machine learning was used to develop an image classifier model, dubbed the "anatomical region classifier," responsible for predicting the location of camera in the upper aerodigestive tract and an object detection model, dubbed the "anatomical structure detector," responsible for locating and identifying key anatomical structures in images. Training data were collected by performing FFL on an AirSim Combo Bronchi X mannikin (United Kingdom, TruCorp Ltd) using an Ambu aScope 4 RhinoLaryngo Slim connected to an Ambu® aView™ 2 Advance Displaying Unit (Ballerup, Ambu A/S).
Article Synopsis
- Preclinical studies suggest that combining MEK inhibition with autophagy or CDK4/6 targeting may be beneficial for pancreatic cancer (PDAC) patients.
- A retrospective analysis of 34 patients treated with trametinib combined with hydroxychloroquine (THCQ) or palbociclib (TP) was conducted to evaluate the effectiveness of these regimens.
- Results showed that both combinations were ineffective, with most patients experiencing disease progression within a short time frame, highlighting the need for better treatment strategies for advanced PDAC with specific genetic mutations.