Study of zinc content in blood serum of the patients with malignant tumors of the digestive systems.

Zinc (Zn)--the important atomavit (essential chemical element), which participates in 120 reactions proceeding in a living organism. There were been found the abnormal Zn-levels in blood in the cases of the various pathologies, including malignant tumors (MT) of the digestive systems. It has been determined the Zn-levels in the blood serum of 48 patients with MT of the digestive systems (nosologies: 24--MT of stomachs, 10--esophagus, 14--colorectum) and 12 practically healthy persons.

Pycnometric, viscometric and calorimetric studies of the process to release the double-stranded DNA from the Un bacteriophage.

Knowledge of both the packaging of the linear, double-stranded (ds)DNA in bacteriophages and its subsequent release into the bacterial host is vital to our understanding of phage infection. There is now strong evidence that packaging requires a powerful rotary motor fuelled by ATP. From thermodynamic studies, however, it has been proposed that, at least for those viruses with a contractile tail, the dsDNA ejection from the phage head is a relatively simple physical process that does not require cellular energy and is facilitated by the difference in the conditions of the medium in the environments inside and outside the head.

[A viscosimetric study of thermally induced release of ds-DNA from Un phage].

The thermally induced ejection of DNA from the head of the Un phage was studied by viscosimetry, pH was used as a variable external factor. The results obtained suggest that the infection of the bacterium by the phage occurs in the pH range 6-10 rather than in the acidic medium (pH 4-5) because the infection can take place only if the DNA is completely ejected from the phage head. It was shown that the ejection of DNA upon dilution of the initial concentration of the phage depends on the time required for the equilibrium of the phage suspension in the corresponding buffer solution to be established after which the measurements can be performed.

[Transmembrane transfer of sodium ions in cell membranes of normal and tumor cells].

Changes of sodium transport in tumor cells and their normal analogs were studied. For the first time we used a direct method of investigation with sodium-selective electrodes which permitted the study of ion transport in dynamics. As a result of investigation of sodium transport on malignant transplanted cultures of fibroblasts (7L strain) and on their normal prototypes--embryonic fibroblasts of hamsters, and also on the cells of Ehrlich ascite tumor--it was shown that when transferred the tumor cells in 15% hypertonic solution significant active transport of ions from the cells into the external medium was recorded.

[Modifying effect of ionizing radiation on the transmembrane transport of sodium ions in Ehrlich carcinoma tumor cells].

The effect of a local X-irradiation on the transmembrane transfer of Na ions and activity of Na-K ATPase in Ehrlich ascites tumor cells has been investigated. Irradiation with doses of 0.05 and 0.