Publications by authors named "D G Smiley"
Article Synopsis
- - Transthyretin cardiac amyloidosis (ATTR-CA) is more commonly diagnosed in older men, but research indicates that women may be underrepresented in previous statistics regarding its prevalence.
- - The SCAN-MP study used nuclear imaging to assess ATTR-CA in older Black and Caribbean Hispanic individuals, revealing that this cohort had a higher percentage of women (31.3%) compared to a referral center (13.3%).
- - Women in the SCAN-MP cohort displayed a less severe form of the disease, indicated by higher heart function and lower heart mass, suggesting that targeted identification in women is essential to address existing sex disparities in ATTR-CA diagnoses.
Article Synopsis
- * The study found that anemia linked to higher risks for all-cause and cardiovascular hospitalizations, with significant statistics demonstrating this correlation.
- * Despite the correlation, when adjusting for age and other factors, anemia was mainly associated with an increased hazard for hospitalizations rather than mortality, highlighting the need for more research on how treating anemia might improve patient outcomes.
Context: Glucose tolerance during an oral glucose tolerance test (OGTT) is affected by variations in glucose effectiveness (GE) and glucose absorption and thus affects minimal model calculations of insulin sensitivity (SI). The widely used OGTT SI by Dalla Man et al. does not account for variances in GE and glucose absorption.
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- The study examines the clinical outcomes of 419 patients diagnosed with transthyretin cardiac amyloidosis (ATTR-CA) from 2001 to 2021, focusing on changes in diagnosis and treatment over time.
- It found that more recent patients are generally older, have less severe disease, and are more likely to be treated with tafamidis, which significantly improves survival rates compared to earlier diagnosed patients.
- Key results show that a higher Columbia score indicates a greater risk of mortality or need for heart transplantation, while tafamidis notably decreases this risk, highlighting the importance of early treatment.