Publications by authors named "D G Shcharbin"
Cancer is one of the most common diseases in developed countries. Recently, gene therapy has emerged as a promising approach to cancer treatment and has already entered clinical practice worldwide. RNA interference-based therapy is a promising method for cancer treatment.
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- * The study introduces third generation PAMAM dendrimers with a thiacalixarene core in three different conformations, found to effectively bind and compact DNA while showing improved binding efficiency with generations.
- * The findings suggest that the structural design of these dendrimers can lower hemotoxicity and potentially simplify the development of new, cost-effective drug delivery systems in nanomedicine.
Solid tumors reprogram metabolic pathways to meet their biosynthesis demands, resulting in elevated levels of metabolites in the tumor microenvironment (TME), including lactate. Excessive accumulation and active transportation of lactate within the TME drives tumor progression, metastasis, and immunosuppression. Interruption of TME lactate metabolism is expected to restore antitumor responses and sensitize tumor immunotherapy.
View Article and Find Full Text PDFNanopolymers represent a significant group of delivery vehicles for hydrophobic drugs. In particular, dual stimuli-responsive smart polymer nanomaterials might be extremely useful for drug delivery and release. We analyzed the possibility to include the known antitumor drug doxorubicin (DOX), which has antimitotic and antiproliferative effects, in a nanopolymer complex.
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