Publications by authors named "D G Rayner"
Objectives: To systematically review the comparative statistical performance (discrimination and /or calibration) of prognostic clinical prediction models (CPMs) and clinician judgment (CJ).
Study Design And Setting: We conducted a systematic review of observational studies in PubMed, Medline, Embase, and CINAHL. Eligible studies reported direct statistical comparison between prognostic CPMs and CJ.
Importance: The optimal inhaled reliever therapy for asthma remains unclear.
Objective: To compare short-acting β agonists (SABA) alone with SABA combined with inhaled corticosteroids (ICS) and with the fast-onset, long-acting β agonist formoterol combined with ICS for asthma.
Data Sources: The MEDLINE, Embase, and CENTRAL databases were searched from January 1, 2020, to September 27, 2024, without language restrictions.
Article Synopsis
- SGLT-2 inhibitors have been shown to provide cardiovascular and kidney benefits for adults with chronic kidney disease (CKD), regardless of whether they have type 2 diabetes or not.
- Current guidelines are incomplete as they do not fully consider the latest evidence or provide specific recommendations based on varying risk levels of CKD progression.
- The guideline panel recommends SGLT-2 inhibitors for adults with CKD, with stronger recommendations for those at higher risk of disease progression and complications.