Publications by authors named "D G Poirier"

Ten coordination compounds, [Cu(L)Cl] (), [Cu(L)NO] (), [Cu(L)Cl] (C3), [Cu(L)NO] (), [Cu(L)Cl] (), [Cu(L)NO] (), [Cu(L)NO] (), [Cu(L)Cl] (), [Cu(L)Cl] (), and [Cu(L)NO] (), containing pyridine derivatives of -methoxyphenyl-thiosemicarbazones were synthesized and characterized. The molecular structure of four compounds was investigated using single crystal X-ray diffraction. Spectral analysis techniques such as FT-IR, H NMR, C NMR, elemental analysis, and molar conductivity were used for all the synthesized compounds.

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  • COVID-19 triage protocols are developed to manage resource shortages in ICUs and have sparked ethical debates, particularly regarding potential biases against certain groups based on age, frailty, or perceived social value.
  • The online Democratic Deliberation conducted in May and June 2022 in Quebec and Ontario aimed to gather public opinions on acceptable considerations and values that should guide these protocols.
  • Analysis revealed three main themes: the need for public acceptance of the protocols, essential considerations to include in triage decisions, and conditions that could enhance acceptance, with participants generally favoring prioritization based on survival prognosis and advocating for structured decision-making to reduce subjectivity.
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  • The 17β-hydroxysteroid dehydrogenases (17β-HSDs) family has multiple isoforms that can convert steroids between their alcohol and carbonyl forms based on the cofactor available.
  • These enzymes play crucial roles in regulating estrogens and androgens, making them promising targets for therapies against conditions like breast cancer, prostate cancer, and Alzheimer's disease.
  • The article reviews recent developments in inhibitors targeting various isoforms, highlighting both traditional and new dual inhibitors, organized by type and research group for clarity.
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Background: Online democratic deliberation (ODD) may foster public engagement in new health strategies by providing opportunities for knowledge exchange between experts, policy makers, and the public. It can favor decision-making by generating new points of view and solutions to existing problems. Deliberation experts recommend gathering feedback from participants to optimize future implementation.

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Unlabelled: Estrogen receptor positive (ER+) breast cancer is the most common subtype of breast cancer and is an age-related disease. The peak incidence of diagnosis occurs around age 70, even though these post-menopausal patients have low circulating levels of estradiol (E2). Despite the hormone sensitivity of age-related tumors, we have a limited understanding of the interplay between systemic and local hormones, chronic inflammation, and immune changes that contribute to the growth and development of these tumors.

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