Implant-guided supracrestal alveolar bone growth using scaffolds, BMP-2, and novel scaffold-retaining device.

Objective: To evaluate the efficacy of various scaffold systems and a Ti scaffold-retaining device with and without non-glycosylated rhBMP-2 (BMP-2) for increasing the vertical alveolar bone growth in the intra-oral mini-pig model.

Methods: Forty-eight Straumann Bone Level implants with hydrophilic (SLActive) surfaces were partially embedded in mandibles of 12 adult mini-pigs with the shoulder of the implant located 3 mm above the bone crest. Twenty-four implants were placed in conjunction with BMP-2 (50 μg) incorporated within resorbable scaffolds.

Comparison of bone morphogenetic protein-2 delivery systems to induce supracrestal bone guided by titanium implants in the rabbit mandible.

Objective: To compare the ability of three non-glycosylated/rhBMP-2 (BMP-2) delivery systems to induce supracrestal bone.

Material And Methods: Thirty-six custom SLActive dental implants were partially embedded in transverse orientation into the posterior mandibles of 18 adult rabbits with the head of the implant located 3 mm supracrestal. Delivery of BMP-2 (30 μg) from the following materials was studied: (1) Ti implant + BMP-2 with hydroxyapatite (HA)-coated collagen (Col/HA) scaffold, (2) Ti implant with Col/HA infused with PEG hydrogel + BMP-2, or (3) Ti implant with HA/β-TCP/PEG hydrogel scaffold + BMP-2.

CBCT evaluation of buccal bone regeneration in postmenopausal women with and without osteopenia or osteoporosis undergoing dental implant therapy.

Statement Of Problem: Because alveolar bone augmentation in women with osteoporosis/osteopenia has an uncertain prognosis, objective and reliable methods should be used to study standard surgical approaches.

Purpose: The purpose of this clinical study was to evaluate bone regeneration 9 months after bone augmentation and implant placement in postmenopausal women with different levels of systemic bone health by using cone beam computed tomography (CBCT) and to test proof of concept for this measurement approach.

Material And Methods: A subset of 14 participants was analyzed in a best practice study of postmenopausal women receiving dental implants and simultaneous horizontal ridge augmentation.

The relationship between implant stability and bone health markers in post-menopausal women with bisphosphonate exposure.

Objectives: The authors assessed the relationship between implant stability and bone turnover markers in patients with and without a history of bisphosphonate (BP) exposure for treatment of osteopenia/osteoporosis.

Materials And Methods: One dental implant site was evaluated in 58 post-menopausal women with a spectrum of bone health in a "best practice" prospective cohort study. Each site had a previous or simultaneous bone augmentation procedure.