Publications by authors named "D G Peckham"
Background: Piperacillin-tazobactam is used in patients with cystic fibrosis to treat recurrent respiratory infections. Exposure is associated with a high frequency of non-immediate hypersensitivity.
Objective: To assess the applicability of the lymphocyte transformation test (LTT) for the diagnosis of piperacillin hypersensitivity and the influence of desensitization on piperacillin-specific T-cell responses.
Article Synopsis
- The study focuses on the detection of ASC aggregates, which are important for inflammasome assembly, particularly the NLRP3 inflammasome, after pyroptotic cell death.
- Researchers developed a method using human monocytes, macrophages, and ASC reporter cells to identify ASC/NLRP3-positive events via flow cytometry.
- Results showed increased ASC/NLRP3 specks in the sera of patients with inflammatory conditions, indicating that FACS is a reliable detection method with potential diagnostic uses in autoinflammatory diseases.
Article Synopsis
- Musculoskeletal issues are common among people with cystic fibrosis (CF), but there’s a lack of accurate data on how often these problems occur and their effects.
- A study surveyed 489 adults from UK CF centers, finding that nearly half experienced musculoskeletal symptoms that impacted daily activities, with back and knee pain being especially prevalent.
- The research concluded that while musculoskeletal symptoms are frequent in CF, they are often not caused by inflammatory arthritis, indicating a need for better understanding and management of these issues.
Background: Cystic fibrosis (CF) is associated with increased resting energy expenditure. However, the introduction of elexacaftor/tezacaftor/ivacaftor (ETI) has resulted in a paradigm shift in nutritional status for many people with CF, with increase body mass index and reduction in the need for nutritional support. While these changes are likely to reflect improved clinical status and an associated downregulation of energy expenditure, they may also reflect drug-induced alterations in metabolic perturbations within CF cells.
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