Effects of instructed and experienced uncertainty on attentional priority.

Previous research has demonstrated that attentional prioritization is shaped by prior experience of reward uncertainty: Attention is more likely to be captured by a stimulus associated with a variable (uncertain) reward than a stimulus that provides diagnostic information about available reward. This finding is noteworthy, because it runs counter to the principle that cognition is motivated to reduce uncertainty and hence surprise. Here we investigated whether this pattern of uncertainty-modulated attentional capture (UMAC) reflects a process of attention for learning, wherein uncertainty-related stimuli are prioritized in an attempt to learn about their true predictive status.

Identification of TAK-756, A Potent TAK1 Inhibitor for the Treatment of Osteoarthritis through Intra-Articular Administration.

Osteoarthritis (OA) is a chronic and degenerative joint disease affecting more than 500 million patients worldwide with no disease-modifying treatment approved to date. Several publications report on the transforming growth factor β-activated kinase 1 (TAK1) as a potential molecular target for OA, with complementary anti-catabolic and anti-inflammatory effects. We report herein on the development of TAK1 inhibitors with physicochemical properties suitable for intra-articular injection, with the aim to achieve high drug concentration at the affected joint, while avoiding severe toxicity associated with systemic inhibition.

Unveiling Gaps in High School Strength and Conditioning: CSCS Certification, Coaching Leadership, and Facilities.

Judge, LW, Marsh, JP, Petersen, JC, Pearson, D, and Bellar, D. Unveiling gaps in high school strength and conditioning: CSCS certification, coaching leadership and facilities. J Strength Cond Res XX(X): 000-000, 2024-The aim of this study was to examine the prevalence of Certified Strength and Conditioning Specialist (CSCS) and/or dedicated strength coaches overseeing strength and conditioning facilities (SCFs) at the high school level in a Southwestern state.

A Leave of Absence Might Not Be a Bad Thing: Registered Practical Nurses Working in Home Care During the COVID-19 Pandemic.

To describe the resilience and emotional intelligence of Registered Practical Nurses working in Home and Community Care during the COVID-19 pandemic. Specifically, to determine if there was a relationship between resilience and emotional intelligence based on whether a nurse: (1) left the sector, (2) considered leaving, or (3) took a leave of absence during the pandemic. An online cross-sectional survey was used to capture respondents' demographic information and scores on the Connor-Davidson Resilience Scale, Resilience at Work Scale, and Wong and Law Emotional Intelligence Scale.