Publications by authors named "D G Parkes"

Finding agreement through a free exchange of views is often difficult. Collective deliberation can be slow, difficult to scale, and unequally attentive to different voices. In this study, we trained an artificial intelligence (AI) to mediate human deliberation.

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Artificial intelligence (AI) and reinforcement learning (RL) have improved many areas but are not yet widely adopted in economic policy design, mechanism design, or economics at large. The AI Economist is a two-level, deep RL framework for policy design in which agents and a social planner coadapt. In particular, the AI Economist uses structured curriculum learning to stabilize the challenging two-level, coadaptive learning problem.

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Article Synopsis
  • Body weight loss of 10% or more can improve liver disease and metabolic issues in most patients with non-alcoholic steatohepatitis (NASH), indicating that metabolic treatments might benefit these individuals.
  • In a study involving obese mice with NASH, the effects of ALT-801—a dual agonist targeting GLP-1 and glucagon—were compared to other drugs like semaglutide and elafibranor over a 12-week period.
  • Results showed that ALT-801 led to significant reductions in body weight, liver fat, inflammation, and fibrosis markers, suggesting it could be an effective therapy for managing NASH compared to the other treatments.
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Amylin, a 37 amino acid peptide pancreatic hormone co-secreted with insulin, normalizes the altered eating patterns induced by chronic stress in the rat. Because these stress-induced changes are driven, in part, by brain corticotropin-releasing factor and corticosterone, and because alterations in the activity of these molecules and the stress system are commonly associated with neuropsychiatric diseases like anxiety, depression, and schizophrenia, we hypothesized that amylin might mitigate behavioral states associated with stress. Therefore, we tested the effects of rat amylin in rodent-based behavioral assays sensitive to neuropsychiatric drugs, including anxiolytic, antidepressant, antipsychotic, and cognitive enhancing drugs: stress-induced hyperthermia (SIH); marble burying; elevated plus maze (EPM)), forced swim test (FST), pre-pulse inhibition, and phencyclidine-induced locomotion.

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