Publications by authors named "D G N G Wijesinghe"

The rapid growth of industry and the global drive for modernization have led to an increase in gas emissions, which present significant environmental and health risks. As a result, there is a growing need for precise and sensitive gas-monitoring technologies. This review delves into the progress made regarding photoacoustic gas sensors, with a specific focus on the vital components of acoustic cells and acoustic detectors.

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Despite combination antiretroviral therapy effectively suppressing HIV within the periphery, neuro-acquired HIV (neuroHIV) remains a significant problem and approximately half of people living with HIV will experience HIV-associated neurocognitive disorders (HAND). Concurrent opioid use exacerbates neuroHIV by promoting neuroinflammation, neuronal injury and synaptodendritic culling, viral replication, and potentially altering antiretroviral concentrations within the brain. The present study examined the effects of HIV and morphine co-exposure on the accumulation and spatial distribution of antiretroviral drugs across multiple regions within the brain in an HIV-1 Tat transgenic mouse model by using infrared-matrix-assisted laser desorption electrospray ionization mass spectrometry imaging (IR-MALDESI MSI).

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Spatial evaluation of the region is associated with the assessment of the Quality of Life (QoL). Despite numerous research endeavoring to define, measure, quantify, and map the quality of life, there exists a consistent fault in Sri Lanka. Hence, the objective of this study was to construct a QoL index and determine the spatial disparities of QoL from the Polpitigma town to its periphery.

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Article Synopsis
  • Reduced fMRI-complexity is linked to Alzheimer's disease progression and correlates strongly with tau levels but not with amyloid deposition.
  • The study investigates the relationship between fMRI-complexity, tau-PET, and amyloid-PET, while also considering the influence of the APOEε4 genetic risk factor.
  • Results indicate that the presence of the APOEε4 allele increases the impact of fMRI-complexity on brain functionality impairment in Alzheimer's disease.
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