Publications by authors named "D G McLeod"
Transthyretin is a thyroid hormone binding protein with a major role in the distribution of thyroid hormones to peripheral tissues. In preeclampsia, the failing placenta releases soluble endoglin into the maternal circulation causing systemic vascular dysfunction. Our group has previously shown that transthyretin binds to soluble endoglin and is taken up as a complex into hepatocytes.
View Article and Find Full Text PDFPurpose: To quantitate regional changes in the outer choroidal vessels in patients with geographic atrophy (GA) in AMD and to correlate with a histopathological donor sample.
Methods: We analyzed 35 participants with GA for in vivo analysis and 1 participant with subject for histopathological analysis. Participants underwent three structural optical coherence tomography scans spaced 6 months apart over 1 year.
Enfortumab vedotin is a novel antibody-drug conjugate (ADC) approved to treat urothelial carcinoma. One rarely reported adverse effect has been life-threatening diabetic ketoacidosis (DKA) driven by profound insulin resistance. We report a case of a 62-year-old nondiabetic woman with metastatic urothelial carcinoma who experienced DKA following her third dose of enfortumab vedotin, with extreme insulin requirements of > 1000 units daily, and full resolution of insulin requirement by day 7 of admission.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to determine if socioeconomic and demographic factors are predictors of follow-up attendance in pediatric patients after kidney stone surgery.
- Researchers analyzed data from 195 pediatric patients who underwent various surgical interventions for kidney stones between 2016 and 2020, focusing on follow-up visit attendance, imaging completion, and urine studies.
- Key findings indicated that lower socioeconomic status, such as public insurance and single-parent households, was linked to decreased follow-up compliance, while prior urology clinic visits increased the likelihood of attending post-op appointments.