Focusing on the Dark Side of the Moon: Involvement of the Nonlesional Skin in Vitiligo.

Research over the last decade has revealed that the normally pigmented skin of patients with vitiligo is not normal at all, as evidenced by alterations in cutaneous morphology and modifications in cellular and metabolic functions that ultimately drive immune activation against melanocytes. Furthermore, nonlesional skin is in a state of subclinical inflammation until triggered by internal and/or external exposomal events. Therefore, targeting early processes that drive immune dysregulation in normally pigmented skin may avoid or reduce melanocyte loss.

[Diagnostic and therapeutic perspectives in RASopathies].

RASopathies are congenital diseases that manifest in childhood with symptoms and potential complications, typically associated with an elevated tumour predisposition risk. The heterogeneous symptoms involve mostly central nervous, cardiovascular, musculoskeletal systems and skin, and modified growth pattern. From molecular perspective, the function of a key protein involved in Ras signalling is impaired, leading to disrupted regulation of cell growth and division.

Comparative Analysis of Medical Interventions to Alleviate Endometriosis-Related Pain: A Systematic Review and Network Meta-Analysis.

: Endometriosis is a chronic condition that affects 6-10% of women of reproductive age, with pain and infertility being its primary symptoms. The most common aspects of pain are overall pelvic pain, dysmenorrhea, and dyspareunia. Our aim was to compare the available medical treatments for endometriosis-related pain.

Symmetry breaking enhances the catalytic and electrocatalytic performance of core/shell tetrametallic porous nanoparticles.

The performance of functional nanocatalysts can be extended by integrating multiple types of metals into well-designed nanoparticles. A porous multimetallic shell grown around high-quality monometallic seeds significantly enhances the availability of active sites. Here, tetrametallic core/shell nanoparticles (Au@mPdPtIr) featuring micro- and mesoporous shells are synthesized with strict control over the overall particle morphology.