Publications by authors named "D G Jeffries"
Rates of evolutionary change vary by gene. While some broad gene categories are highly conserved with little divergence over time, others undergo continuous selection pressure and are highly divergent. Here, we combine single-cell RNA sequencing (scRNAseq) with evolutionary genomics to understand whether certain cell types exhibit faster evolutionary divergence (using their characteristic genes), than other types of cells.
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- * It describes a study that analyzed data from a trial in The Gambia focusing on micronutrient supplementation and how heat stress affects various growth measurements at birth and within the first two years of life.
- * Findings indicated that in the first trimester, increased heat exposure correlated with lower weight-for-gestational-age Z scores, while in the third trimester, heat exposure showed a slight increase in head circumference-for-gestational-age Z scores, though the latter was not statistically significant.
Hybridization plays a pivotal role in evolution, influencing local adaptation and speciation. However, it can also reduce biodiversity, which is especially damaging when native and non-native species meet. Hybridization can threaten native species via competition (with vigorous hybrids), reproductive resource wastage and gene introgression.
View Article and Find Full Text PDFBackground: An estimated 3.5 million people in the UK live with a rare disease however due to the rarity of each individual condition this is not currently reflected in mainstream medical education. As a result, common features of living with a rare condition include diagnostic delay, poor coordination of health and social care and lack of access to specialist care and treatment.
View Article and Find Full Text PDFBackground: Microneedle patches (MNPs) have been ranked as the highest global priority innovation for overcoming immunisation barriers in low-income and middle-income countries. This trial aimed to provide the first data on the tolerability, safety, and immunogenicity of a measles and rubella vaccine (MRV)-MNP in children.
Methods: This single-centre, phase 1/2, double-blind, double-dummy, randomised, active-controlled, age de-escalation trial was conducted in The Gambia.