Role of quantitative imaging biomarkers in an early FDG-PET/CT for detection of immune-related adverse events in melanoma patients: a prospective study.

Background: To evaluate the role of the novel quantitative imaging biomarker (QIB) SUV of F-FDG uptake extracted from early F-FDG-PET/CT scan at 4 weeks for the detection of immune-related adverse events (rAE) in a cohort of patients with metastatic melanoma (mM) patients receiving immune-checkpoint inhibitors (ICI).

Patients And Methods: In this prospective non-interventional, one-centre clinical study, patients with mM, receiving ICI treatment, were regularly followed by F-FDG PET/CT. Patients were scanned at baseline, early point at week four (W4), week sixteen (W16) and week thirty-two (W32) after ICI initiation.

Assessing the Heterogeneity of Response of [Ga] Ga-PSMA-11 PET/CT Lesions in Patients With Biochemical Recurrence of Prostate Cancer.

Introduction: Treatment of men with metastatic prostate cancer can be difficult due to the heterogeneity of response of lesions. [Ga]Ga-PSMA-11 (PSMA) PET/CT assists with monitoring and directing clinical intervention; however, the impact of response heterogeneity has yet to be related to outcome measures. The aim of this study was to assess the impact of quantitative imaging information on the value of PSMA PET/CT to assess patient outcomes in response evaluation.

Optimal Controller Identification for multivariable non-minimum phase systems.

This work deals with data-driven control for non-minimum phase (NMP) systems, where the goal is to design a controller for a plant whose model is unknown by using a batch of input-output data collected from it. The approach is based on the Model Reference paradigm, where a transfer function matrix - the reference model - is used to specify the desired closed-loop performance. The NMP systems issue in Model Reference approaches is a well-known problem in control literature and it is no different in data-driven methods.

Performing Lower-Limb Strength Exercises Before or After Training Does not Influence Fatigue Indices in Competitive Youth Soccer Players.

Gantzer, C, Huff, D, Butterick, B, Chalmers, S, Marshall, P, Lovell, R, and Siegler, JC. Performing lower-limb strength exercises before or after training does not influence fatigue indices in competitive youth soccer players. J Strength Cond Res XX(X): 000-000, 2024-A multicenter approach was used to conduct a controlled, laboratory-based study (Part A) in conjunction with an ecologically focused, field-based study (Part B) of the influence of timing on hamstring fatigue induced by lower-limb strength exercises.

Chinook salmon depth distributions on the continental shelf are shaped by interactions between location, season, and individual condition.

Background: Ecological and physical conditions vary with depth in aquatic ecosystems, resulting in gradients of habitat suitability. Although variation in vertical distributions among individuals provides evidence of habitat selection, it has been challenging to disentangle how processes at multiple spatio-temporal scales shape behaviour.

Methods: We collected thousands of observations of depth from acoustically tagged adult Chinook salmon Oncorhynchus tshawytscha, spanning multiple seasons and years.