Publications by authors named "D G Hollis"
The primary objective was to compare sensory processing measures in people attending specialist orthopaedic consultation for management of persistent shoulder pain with control participants. The secondary objective was to compare the groups' sociodemographic, clinical, general health and lifestyle, and psychological characteristics. Observational cross-sectional.
View Article and Find Full Text PDFArticle Synopsis
- DNA experiences high mechanical stress from bending and twisting in various biological structures, such as nucleosomes and virus capsids, affecting essential processes like packaging and gene regulation.
- A new ligation assay developed on nicked DNA circles shows that DNA can unwind to over 11 base pairs per turn when curving tightly, challenging the conventional belief that its helical structure remains consistent.
- This research necessitates a re-evaluation of DNA's mechanical model and its implications for molecular processes involving tightly bent DNA.
Background: Musculoskeletal shoulder pain is a common problem and its symptoms often become persistent. The experience of pain is multidimensional, and therefore, a range of patient characteristics may influence treatment response. An altered sensory processing has been associated with persistent musculoskeletal pain states and may contribute to outcomes in patients with musculoskeletal shoulder pain.
View Article and Find Full Text PDFArticle Synopsis
- Fibrotic scarring is common in collagen disorders, and understanding the biophysical aspects of the fibrotic matrix can help in developing better therapies and insights into biological processes.
- The study uses a technique called microfocus small-angle X-ray scattering (SAXS) combined with other imaging methods to analyze the fibrotic matrix in keloid scars, revealing complex structures and variations in collagen properties at the nanoscale.
- The researchers demonstrate that this method can measure and quantify changes in fibrillar alignment and behavior under stress, offering a new way to investigate the relationship between structure and function in fibrotic tissues.
Extreme weather events have become a dominant feature of the narrative surrounding changes in global climate with large impacts on ecosystem stability, functioning and resilience; however, understanding of their risk of co-occurrence at the regional scale is lacking. Based on the UK Met Office's long-term temperature and rainfall records, we present the first evidence demonstrating significant increases in the magnitude, direction of change and spatial co-localisation of extreme weather events since 1961. Combining this new understanding with land-use data sets allowed us to assess the likely consequences on future agricultural production and conservation priority areas.
View Article and Find Full Text PDF